Family

Glucose-6-phosphate dehydrogenase (IPR001282)

Short name: G6P_DH

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Glucose-6-phosphate dehydrogenase (EC:1.1.1.49) (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types [PMID: 2838391]. The enzyme catalyses the the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous expression of the enzyme gives it a major role in the production of NADPH for the many NADPH-mediated reductive processes in all cells [PMID: 3393536]. Deficiency of G6PDH is a common genetic abnormality affecting millions of people worldwide. Many sequence variants, most caused by single point mutations, are known, exhibiting a wide variety of phenotypes [PMID: 3393536].

GO terms

Biological Process

GO:0006006 glucose metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS
PANTHER
PIRSF
TIGRFAMs
HAMAP