InterPro-
Overview
Glucose-6-phosphate dehydrogenase (IPR001282)
Short name: G6P_DH
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
Glucose-6-phosphate dehydrogenase (EC:1.1.1.49) (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types [PMID: 2838391]. The enzyme catalyses the the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous expression of the enzyme gives it a major role in the production of NADPH for the many NADPH-mediated reductive processes in all cells [PMID: 3393536]. Deficiency of G6PDH is a common genetic abnormality affecting millions of people worldwide. Many sequence variants, most caused by single point mutations, are known, exhibiting a wide variety of phenotypes [PMID: 3393536].
GO terms
Biological Process
GO:0006006 glucose metabolic process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0004345 glucose-6-phosphate dehydrogenase activity
Cellular Component
No terms assigned in this category.
Contributing signatures
- MF_00966 (G6PD)
- PTHR23429 (PTHR23429)
- PIRSF000110 (G6PD)
- PR00079 (G6PDHDRGNASE)
- TIGR00871 (zwf)
