CXC chemokine receptor 4/atypical chemokine receptor 2 (IPR001277)

Short name: CXCR4/ACKR2

Overlapping homologous superfamilies


Family relationships


CXC chemokine receptor 4 (CXCR4), also known as fusin, which is a specific receptor for a CXCL12 (or SDF1). CXCR4 has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types [PMID: 9261420, PMID: 10985313, PMID: 12055238, PMID: 11154210, PMID: 11435493]. In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cells [PMID: 9461627]. Upon binding to CXCR4, CXCL12 causes mobilisation of intracellular calcium and chemotaxis [PMID: 11876757, PMID: 12370187, PMID: 10525044]. CXCL12 is known to be important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence. CXCR4 has a rather broad activity, and has been linked to cardiac, cerebellar gastric vasculature development [PMID: 9634238, PMID: 11983855] and to hematopoiesis [PMID: 18378795].

Atypical chemokine receptor 2 (ACKR2/D6) [PMID: 19130487] is a chemokine-scavenging receptor or chemokine decoy receptor. It is capable of internalising and effectively scavenging its ligands through beta-arrestin-dependent activation of the cofilin pathway [PMID: 12594248, PMID: 15004236]. ACKR2 is highly promiscuous and can bin the majority of (if not all) inflammatory CC-chemokines [PMID: 26097478]. It plays an essential role in the resolution of the inflammatory response [PMID: 23479571, PMID: 15750596, PMID: 23125030]. Although it lacks the canonical DRYLAIV motif necessary for classical signalling, ACKR2/D6 may be involved in 'atypical' signaling pathways downstream of ligand binding [PMID: 23633677]. It has been shown to be involved in regulating vessel density [PMID: 25271254].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.