Domain

DM DNA-binding domain (IPR001275)

Short name: DM_DNA-bd

Domain relationships

None.

Description

This domain was first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in proteins from Caenorhabditis elegans [PMID: 9490411]. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides [PMID: 8978051]. These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription [PMID: 1907913, PMID: 3046751]. The DM domain binds DNA as a dimer, allowing the recognition of pseudopalindromic sequences [PMID: 8978051, PMID: 9927589, PMID: 10898790]. The NMR analysis of the DSX DM domain [PMID: 10898790] revealed a novel zinc module containing 'intertwined' CCHC and HCCC zinc-binding sites. The recognition of the DNA requires the carboxy-terminal basic tail which contacts the minor groove of the target sequence.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0043565 sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
Pfam
GENE3D
PROSITE profiles
SUPERFAMILY
SMART