Domain

DM DNA-binding domain (IPR001275)

Short name: DM_DNA-bd

Domain relationships

None.

Description

DMRT genes encode a conserved family of transcription factors that share a unique DNA binding motif, the DM domain [PMID: 28774758]. This domain was first discovered in the doublesex proteins of Drosophila melanogaster [PMID: 9490411]. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides [PMID: 8978051]. These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription [PMID: 1907913, PMID: 3046751]. The DM domain binds DNA as a dimer, allowing the recognition of pseudopalindromic sequences [PMID: 8978051, PMID: 9927589, PMID: 10898790]. The NMR analysis of the DSX DM domain [PMID: 10898790] revealed a novel zinc module containing 'intertwined' CCHC and HCCC zinc-binding sites. The recognition of the DNA requires the carboxy-terminal basic tail which contacts the minor groove of the target sequence.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0043565 sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles
PROSITE patterns
SMART