Family

Thymidine kinase (IPR001267)

Short name: Thymidine_kinase

Overlapping homologous superfamilies

Family relationships

None.

Description

Thymidine kinase (TK) (EC:2.7.1.21) is an ubiquitous enzyme that catalyzes the ATP-dependent phosphorylation of thymidine.

Two different families of thymidine kinase have been identified [PMID: 3027984, PMID: 2389555] and are represented in this entry; one groups together thymidine kinase from herpesviruses, as well as cytosolic thymidylate kinases and the second family groups thymidine kinase from various sources that include, vertebrates, bacteria, the bacteriophage T4, poxviruses, African swine fever virus (ASFV) and fish lymphocystis disease virus (FLDV). The major capsid protein of insect iridescent viruses also belongs to this family.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0004797 thymidine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
HAMAP
Pfam
PANTHER