Domain

Mannose-binding lectin (IPR001229)

Short name: Mannose-bd_lectin

Domain relationships

None.

Description

This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein. Proteins containing this domain include:

  • Jacalin, a tetrameric plant seed lectin and agglutinin from Artocarpus heterophyllus (jackfruit), which is specific for galactose [PMID: 12206779].
  • Artocarpin, a tetrameric plant seed lectin from A. heterophyllus [PMID: 15099743].
  • Lectin MPA, a tetrameric plant seed lectin and agglutinin from Maclura pomifera (Osage orange), [PMID: 9497359].
  • Heltuba lectin, a plant seed lectin and agglutinin from Helianthus tuberosus (Jerusalem artichoke) [PMID: 10647178].
  • Agglutinin from Calystegia sepium (Hedge bindweed) [PMID: 14561768].
  • Griffithsin, an anti-viral lectin from red algae (Griffithsia species) [PMID: 16843894].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam
SUPERFAMILY
GENE3D