Family

Phenol hydroxylase reductase (IPR001221)

Short name: Phe_hydroxylase

Family relationships

Description

Flavoprotein pyridine nucleotide cytochrome reductases [PMID: 1748631] (FPNCR) catalyse the interchange of reducing equivalents between one-electron carriers and the two-electron-carrying nicotinamide dinucleotides. The enzymes include ferredoxin:NADP+ reductases (FNR); plant and fungal NAD(P)H:nitrate reductases; NADH:cytochrome b5 reductases; NADPH:P450 reductases; NADPH:sulphite reductases; nitric oxide synthases; phthalate dioxygenase reductase; and various other flavoproteins.

Dioxygen can be incorporated directly into organic compounds in reactions catalysed by enzymes termed oxygenases or hydroxylases: oxygenases that catalyse the incorporation of both atoms of dioxygen into substrates are known as dioxygenases; those that catalyse the incorporation of only one atom of dioxygen are termed monooxygenases, or mixed-function oxygenases. The second atom of dioxygen is reduced to H2O either by the substrates themselves or by a co-substrate reductant [PMID: 1444267].

Electron transfer components of a number of bacterial multi-component aromatic-ring and alkyl-group oxygenases (including phenol hydroxylase [PMID: 2254258], benzoate 1,2-dioxygenase [PMID: 1885518], toluate 1,2-dioxygenase [PMID: 1938949], xylene monooxygenase [PMID: 1999388] and methane monooxygenase [PMID: 2205538]), belong to family of [2Fe-2S] ferredoxin/FPNCR fusion proteins. Other members of the family are Yersinia pseudotuberculosis CDP-6-deoxy-3,4-glucoseen reductase [PMID: 8444803] and S.typhimurium rfbI protein [PMID: 1710759]. All contain a [2Fe-2S] ferredoxin domain fused to the N terminus of an FPNCR domain. The direction of electron flow is from flavin to the [2Fe-2S] centre.

Phenol hydroxylase [PMID: 2254258], benzoate-1,2-dioxygenase [PMID: 1885518], toluate-1,2-dioxygenase [PMID: 1938949], xylene monooxygenase [PMID: 1999388] and methane monooxygenase [PMID: 2205538] contain an oxidoreductase FAD/NAD(P)-binding domain. They are the electron transfer components of a number of bacterial multi-component aromatic-ring and alkyl-group oxygenases.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS