Domain

RNA-directed RNA polymerase, C-terminal domain (IPR001205)

Short name: RNA-dir_pol_C

Domain relationships

None.

Description

This entry represents the C-terminal domain of the RNA-directed RNA polymerase found in many positive strand RNA eukaryotic viruses viruses. It is part of the genome polyprotein that contains other polypeptides such as coat proteins VP1 to VP4, core proteins P2A to P2C and P3A, genome-linked protein VPG and picornain 3C (EC:3.4.22.28).

Structural studies indicate that these proteins form the "right hand" structure found in all oligonucleotide polymerases, containing thumb, finger and palm domains, and also the additional bridging finger and thumb domains unique to RNA-directed RNA polymerases [PMID: 15306852, PMID: 15296746].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

GO:0003723 RNA binding
GO:0003968 RNA-directed 5'-3' RNA polymerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam