Tissue factor (IPR001187)

Short name: Tissue_factor

Overlapping homologous superfamilies

Family relationships



Tissue factor (TF, also known as thromboplastin) is an integral membrane glycoprotein that initiates blood coagulation by forming a complex with circulating factor VII (FVII) or VIIa (FVIIa), which it comes in contact with following damage to blood vessel walls. Calcium forms the bridge between TF and FVII, the resultant TF/FVII undergoing auto-cleavage to produce activated TF/FVIIa. This activation sets off an extracellular cascade involving sequential serine protease activations, where TF/FVIIa converts FIX to FIXa, followed by a series of reactions to finally produce fibrin, leading to fibrin deposition and the activation of platelets to form clots [PMID: 15569823, PMID: 16261634].

Tissue Factor plays many diverse roles, and in addition to promoting blood coagulation, it is involved in inflammation, embryonic development, angiogenesis, tumour metastasis, cell adhesion/migration, and innate immunity [PMID: 16479459]. For example, TF plays an important role in inflammation, since the extracellular blood coagulation signalling pathway can trigger an intracellular inflammation-signalling pathway [PMID: 16036212, PMID: 14872439]. TF activation leads to the production of activated factors FVIIa, FXa and FIIa, which in turn can activate PAR (protease-activated receptors) receptors, resulting in the expression of a variety of inflammatory molecules.

The extracellular domain of tissue factor, which accounts for over 80% of the protein, contains two domains with the same structural fold as fibronectin type III, consisting of an immunoglobulin-like beta-sandwich with a Greek key topology.

GO terms

Biological Process

GO:0007596 blood coagulation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.