Large-conductance mechanosensitive channel (IPR001185)

Short name: MS_channel

Overlapping homologous superfamilies

Family relationships


Mechanosensitive ion channels (MscL) play a critical role in transducing physical stresses at the cell membrane into an electrochemical response. MscL is a protein which forms a channel organised as a homopentamer, with each subunit containing two transmembrane regions [PMID: 9856938]. Prokaryotes harbor a large-conductance mechanosensitive channel (gene mscL) that opens in response to stretch forces in the membrane lipid bilayer and may participate in the regulation of osmotic pressure changes within the cell [PMID: 9632260].

GO terms

Biological Process

GO:0034220 ion transmembrane transport

Molecular Function

GO:0008381 mechanosensitive ion channel activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.