Adenylyl cyclase class-4/guanylyl cyclase (IPR001170)

Short name: ANPR/GUC

Overlapping homologous superfamilies

Family relationships



This entry includes the natriuretic peptide receptors (ANP-A, ANP-B and ANP-C) from animals [PMID: 15146390, PMID: 10377427] and guanylate cyclases 2G (GUC2G) from rodents. GUC2G is closely related to the natriuretic peptide receptors, but all ligands known to activate other receptors failed to stimulate its enzymic activity [PMID: 14713286].

Natriuretic peptides are hormones involved in the regulation of fluid and electrolyte homeostasis. These hormones stimulate the intracellular production of cyclic GMP as a second messenger. They belong to a family that includes extracellular ligand binding domains of a wide range of receptors. Three peptide receptors are known, two of which express quanylate cyclase activity (GC-A or ANP-A, and GC-B or ANP-B), while the third (ANP-C) is probably responsible for the clearance of atrial natriuretic peptide (ANP) from the circulation and does not play a role in signal transduction [PMID: 1978722, PMID: 2568301].

GC-A and GC-B are plasma membrane-bound proteins that share the following topology: an N-terminal extracellular domain which acts as the ligand binding region, then a transmembrane domain followed by a large cytoplasmic C-terminal region that can be subdivided into two domains: a protein kinase-like domain IPR000719 that appears important for proper signalling and a guanylate cyclase catalytic domain IPR001054. The topology of ANP-C is different: like GC-A and -B it possesses an extracellular ligand-binding region and a transmembrane domain, but its cytoplasmic domain is very short.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns