Peptidase M20C, Xaa-His dipeptidase (IPR001160)

Short name: Peptidase_M20C

Overlapping homologous superfamilies


Family relationships

  • Peptidase M20 (IPR002933)
    • Peptidase M20C, Xaa-His dipeptidase (IPR001160)


This majority of this group of proteins are aminoacyl-histidine dipeptidases (Xaa-His dipeptidases, cytosol non-specific dipeptidases, peptidase D), which are zinc-containing metallopeptidases that belong to MEROPS peptidase family M20 (clan MH), subfamily M20C [PMID: 7674922]. Proteins of this clan have two catalytic zinc ions at the active site, bound by His/Asp, Asp, Glu, Asp/Glu and His [PMID: 7674922, PMID: 1695895]. The catalysed reaction involves the release of an N-terminal amino acid, usually neutral or hydrophobic, from a polypeptide [PMID: 7674922].

The X-His dipeptidases cleave Xaa-His dipeptides (where Xaa is any hydrophobic residue). The amino acid sequence deduced from Escherichia coli reveals that peptidase D is a slightly hydrophilic protein of 485 residues that contains no extended domains of marked hydrophobicity [PMID: 1695895].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.