Family

Beta-thymosin (IPR001152)

Short name: Beta-thymosin

Family relationships

None.

Description

This entry represents beta-thymosin family. Its members include thymosin beta-4, -10, -15 from humans and their homologues (such as thymosin beta 11/12) from fish.

Thymosin beta-4 (Tbeta) is a small protein that sequesters actin monomers to help maintain the high concentrations of unpolymerised actin in higher eukaryotic cells. Its structure has been resolved [PMID: 25313062]. It is a multiple function protein that plays important roles in cellular processes such as wound healing, embryonic organ development and the pathogeneses of disease [PMID: 24993983, PMID: 24732964]. It plays a role in anti-apoptotic response to an external stress [PMID: 15037574], paclitaxel-resistance via ROS production [PMID: 18306930, PMID: 20637781] and HIF-1alpha stabilisation via Erk activation [PMID: 18272284]. It also regulates cancer cell migration through various signalling pathways, and hence plays a role in malignant progression and invasion in colon adenocarcinoma [PMID: 22328534, PMID: 12761500].

Thymosin beta-15 has been reported to be up-regulated in breast, brain, lung and head and neck cancer [PMID: 17567946]. The expression of thymosin beta-10 is also associated with many cancers [PMID: 24053380].

GO terms

Biological Process

GO:0007015 actin filament organization

Molecular Function

GO:0003785 actin monomer binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
PIRSF
Pfam
PROSITE patterns
PANTHER
ProDom