Pathways & interactions
Short name: Beta-thymosin
This entry represents beta-thymosin family. Its members include thymosin beta-4, -10, -15 from humans and their homologues (such as thymosin beta 11/12) from fish.
Thymosin beta-4 (Tbeta) is a small protein that sequesters actin monomers to help maintain the high concentrations of unpolymerised actin in higher eukaryotic cells. Its structure has been resolved [PMID: 25313062]. It is a multiple function protein that plays important roles in cellular processes such as wound healing, embryonic organ development and the pathogeneses of disease [PMID: 24993983, PMID: 24732964]. It plays a role in anti-apoptotic response to an external stress [PMID: 15037574], paclitaxel-resistance via ROS production [PMID: 18306930, PMID: 20637781] and HIF-1alpha stabilisation via Erk activation [PMID: 18272284]. It also regulates cancer cell migration through various signalling pathways, and hence plays a role in malignant progression and invasion in colon adenocarcinoma [PMID: 22328534, PMID: 12761500].
Thymosin beta-15 has been reported to be up-regulated in breast, brain, lung and head and neck cancer [PMID: 17567946]. The expression of thymosin beta-10 is also associated with many cancers [PMID: 24053380].
- PTHR12021 (PTHR12021)
- PD005116 (Thymosin_b4)
- SM00152 (THY)
- PS00500 (THYMOSIN_B4)
- G3DSA:184.108.40.2060 (G3DSA:220.127.116.110)
- PIRSF001828 (Thymosin_beta)
- PF01290 (Thymosin)