ABC transporter, transmembrane domain (IPR001140)

Short name: ABC_transptr_TM_dom

Domain relationships


A variety of ATP-binding transport proteins have a six transmembrane helical region. They are all integral membrane proteins involved in a variety of transport systems. Members of this family include; the cystic fibrosis transmembrane conductance regulator (CFTR), bacterial leukotoxin secretion ATP-binding protein, multidrug resistance proteins, the yeast leptomycin B resistance protein, the mammalian sulphonylurea receptor and antigen peptide transporter 2. Many of these proteins have two such regions.

This domain represents a unit of six transmembrane helices. Many members of the ABC transporter family have two such regions.

GO terms

Biological Process

GO:0055085 transmembrane transport
GO:0006810 transport

Molecular Function

GO:0005524 ATP binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.