Domain

Transforming growth factor-beta, N-terminal (IPR001111)

Short name: TGF-b_N

Domain relationships

None.

Description

The transforming growth factor beta, N terminus (TGFb) domain is present in a variety of proteins which include the transforming growth factor beta, decapentaplegic proteins and bone morphogenetic proteins. Transforming growth factor beta is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. The decapentaplegic protein acts as an extracellular morphogen responsible for the proper development of the embryonic dorsal hypoderm, for viability of larvae and for cell viability of the epithelial cells in the imaginal disks. Bone morphogenetic protein induces cartilage and bone formation and may be responsible for epithelial osteogenesis in some organisms.

GO terms

Biological Process

GO:0040007 growth

Molecular Function

GO:0008083 growth factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam