Family

Hydrogenase expression/formation protein, HupF/HypC (IPR001109)

Short name: Hydrogenase_HupF/HypC

Family relationships

None.

Description

The large subunit of [NiFe]-hydrogenase, as well as other nickel metalloenzymes, is synthesised as a precursor devoid of the metalloenzyme active site. This precursor then undergoes a complex post-translational maturation process that requires a number of accessory proteins. The hydrogenase expression/formation proteins (HupF/HypC) form a family of small proteins that are hydrogenase precursor-specific chaperones required for this maturation process [PMID: 8497190]. They are believed to keep the hydrogenase precursor in a conformation accessible for metal incorporation [PMID: 9485446, PMID: 10783387].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PRINTS
TIGRFAMs