Transglutaminase, N-terminal (IPR001102)

Short name: Transglutaminase_N

Overlapping homologous superfamilies

Domain relationships



Synonym(s): Protein-glutamine gamma-glutamyltransferase, Fibrinoligase, TGase

Protein-glutamine gamma-glutamyltransferases (EC: (TGase) are calcium-dependent enzymes that catalyse the cross-linking of proteins by promoting the formation of isopeptide bonds between the gamma-carboxyl group of a glutamine in one polypeptide chain and the epsilon-amino group of a lysine in a second polypeptide chain. TGases also catalyse the conjugation of polyamines to proteins [PMID: 1683845, PMID: 1974250].

Transglutaminases are widely distributed in various organs, tissues and body fluids. The best known transglutaminase is blood coagulation factor XIII, a plasma tetrameric protein composed of two catalytic A subunits and two non-catalytic B subunits. Factor XIII is responsible for cross-linking fibrin chains, thus stabilising the fibrin clot.

There are commonly three domains: N-terminal, middle (IPR013808) and C-terminal (IPR008958). This entry represents the N-terminal domain found in transglutaminases.

GO terms

Biological Process

GO:0018149 peptide cross-linking

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.