Domain

Transglutaminase, N-terminal (IPR001102)

Short name: Transglutaminase_N

Domain relationships

Description

Synonym(s): Protein-glutamine gamma-glutamyltransferase, Fibrinoligase, TGase

Protein-glutamine gamma-glutamyltransferases (EC:2.3.2.13) (TGase) are calcium-dependent enzymes that catalyse the cross-linking of proteins by promoting the formation of isopeptide bonds between the gamma-carboxyl group of a glutamine in one polypeptide chain and the epsilon-amino group of a lysine in a second polypeptide chain. TGases also catalyse the conjugation of polyamines to proteins [PMID: 1683845, PMID: 1974250].

Transglutaminases are widely distributed in various organs, tissues and body fluids. The best known transglutaminase is blood coagulation factor XIII, a plasma tetrameric protein composed of two catalytic A subunits and two non-catalytic B subunits. Factor XIII is responsible for cross-linking fibrin chains, thus stabilising the fibrin clot.

There are commonly three domains: N-terminal, middle (IPR013808) and C-terminal (IPR013807). This entry represents the N-terminal domain found in transglutaminases.

GO terms

Biological Process

GO:0018149 peptide cross-linking

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam