Family

Acetyl-CoA carboxylase, alpha subunit (IPR001095)

Short name: Acetyl_CoA_COase_a_su

Family relationships

None.

Description

This entry contains the alpha subunit the acetyl coenzyme A carboxylase complex (EC:6.4.1.2). It catalyses the first step in the synthesis of long-chain fatty acids which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association [PMID: 1355089]. The reaction involves two steps:

Biotin carrier protein + ATP + HCO3- -> Carboxybiotin carrier protein + ADP + Pi Carboxybiotin carrier protein + Acetyl-CoA -> Malonyl-CoA + Biotin carrier protein

GO terms

Biological Process

GO:0006633 fatty acid biosynthetic process

Molecular Function

GO:0003989 acetyl-CoA carboxylase activity

Cellular Component

GO:0009317 acetyl-CoA carboxylase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS
TIGRFAMs
HAMAP
Pfam