Serine hydroxymethyltransferase (IPR001085)

Short name: Ser_HO-MeTrfase

Family relationships


This entry includes serine hydroxymethyltransferases, fluorothreonine transaldolases and other uncharacterised proteins.

Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) dependent enzyme and belongs to the aspartate aminotransferase superfamily (fold type I) [PMID: 10828359]. The pyridoxal-P group is attached to a lysine residue around which the sequence is highly conserved in all forms of the enzyme [PMID: 8305478]. The enzyme carries out interconversion of serine and glycine using PLP as the cofactor. SHMT catalyses the transfer of a hydroxymethyl group from N5, N10- methylene tetrahydrofolate to glycine, resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers and the mammalian enzyme forms a homotetramer [PMID: 10828359, PMID: 11877399].

GO terms

Biological Process

GO:0006545 glycine biosynthetic process
GO:0035999 tetrahydrofolate interconversion

Molecular Function

GO:0004372 glycine hydroxymethyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.