2-oxoacid dehydrogenase acyltransferase, catalytic domain (IPR001078)

Short name: 2-oxoacid_DH_actylTfrase

Overlapping homologous superfamilies

Domain relationships



This domain is found in the lipoamide acyltransferase component of the branched-chain alpha-keto acid dehydrogenase complex EC:2.3.1, which catalyses the overall conversion of alpha-keto acids to acyl-CoA and carbon dioxide [PMID: 8487300]. It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). The domain is also found in the dihydrolipoamide succinyltransferase component of the 2-oxoglutarate dehydrogenase complex EC: These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016746 transferase activity, transferring acyl groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.