O-methyltransferase, family 2 (IPR001077)

Short name: O_MeTrfase_2

Overlapping homologous superfamilies

Domain relationships



This domain includes a range of O-methyltransferases some of which utilise S-adenosyl methionine as substrate [PMID: 8434913]. In prokaryotes, the major role of DNA methylation is to protect host DNA against degradation by restriction enzymes. In eukaryotes, DNA methylation has been implicated in the control of several cellular processes, including differentiation, gene regulation, and embryonic development. O-methyltransferases have a common catalytic domain structure, which might be universal among S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases [PMID: 7773746].

Comparative analysis of the predicted amino acid sequences of a number of plant O-methyltransferase cDNA clones show that they share some 32-71% sequence identity, and can be grouped according to the different compounds they utilise as substrates [PMID: 9484457].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008171 O-methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.