Nuclear translocator (IPR001067)

Short name: Nuc_translocat

Overlapping homologous superfamilies

Family relationships



The Ah (dioxin) receptor nuclear translocator protein (Arnt) belongs to the basic helix-loop-helix (bHLH) family of transcription factors and is required for Ah receptor function. The Ah receptor binds, and mediates the carcinogenic effects of a variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Arnt is a structural component of the XRE-binding form of the Ah receptor. These proteins are class VII members of the basic helix-loop-helix (bHLH) family. The bHLH domain may be responsible for interacting with both the XRE and the ligand-binding subunit [PMID: 8065341, PMID: 1317062].

The activated Ah receptor and Arnt protein bind DNA as a heterodimer. Both proteins contain PAS homology regions, which in Drosophila PER and SIM proteins function as dimerisation domains [PMID: 8065341].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus
GO:0005667 transcription factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.