NRAMP family (IPR001046)

Short name: NRAMP_fam

Overlapping homologous superfamilies


Family relationships


The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functionally related proteins defined by a conserved hydrophobic core of ten transmembrane domains [PMID: 7479731]. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others. It is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals [PMID: 9719491]. The yeast proteins Smf1 and Smf2 may also transport divalent cations [PMID: 9632246].

The natural resistance of mice to infection with intracellular parasites is controlled by the Bcg locus, which modulates the cytostatic/cytocidal activity of phagocytes. Nramp1, the gene responsible, is expressed exclusively in macrophages and poly-morphonuclear leukocytes, and encodes a polypeptide (natural resistance-associated macrophage protein) with features typical of integral membrane proteins. Other transporter proteins from a variety of sources also belong to this family.

GO terms

Biological Process

GO:0030001 metal ion transport

Molecular Function

GO:0046873 metal ion transmembrane transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.