XPG/Rad2 endonuclease, eukaryotes (IPR001044)

Short name: XPG/Rad2_eukaryotes

Overlapping homologous superfamilies

Family relationships


This entry represents XPG (also known as Rad2 in budding yeast, AtRAD2 or UVH3 in Arabidopsis and Rad13 in fission yeast), a single-stranded structure-specific DNA endonuclease, which cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA [PMID: 22863773].

In Saccharomyces cerevisiae, Rad2 forms the Nucleotide Excision Repair Factor 3 (NEF3) complex with a subset of subunits of the transcription factor TFIIH [PMID: 8855246]. Besides DNA damage repair, it is also required for efficient transcription [PMID: 12110180].

Defects in XPG are the cause of xeroderma pigmentosum complementation group G (XP-G), which is an autosomal recessive pigmentary skin disorder characterised by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities [PMID: 7951246].

GO terms

Biological Process

GO:0006289 nucleotide-excision repair

Molecular Function

GO:0004519 endonuclease activity
GO:0003697 single-stranded DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.