Translation Initiation factor eIF- 4e (IPR001040)

Short name: TIF_eIF_4E

Overlapping homologous superfamilies

Family relationships



Eukaryotic translation initiation factor 4E (eIF-4E) [PMID: 1733496] is a protein that binds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding [PMID: 1672854].

GO terms

Biological Process

GO:0006413 translational initiation

Molecular Function

GO:0003723 RNA binding
GO:0003743 translation initiation factor activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.