Thioesterase (IPR001031)

Short name: Thioesterase

Overlapping homologous superfamilies

Domain relationships


Thioesterase domains often occur integrated in or associated with peptide synthetases which are involved in the non-ribosomal synthesis of peptide antibiotics [PMID: 9560421]. Thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates.

GO terms

Biological Process

GO:0009058 biosynthetic process

Molecular Function

GO:0016788 hydrolase activity, acting on ester bonds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.