Flagellin, D0/D1 domain (IPR001029)

Short name: Flagellin_D0/D1

Domain relationships



Bacterial flagella are responsible for motility and chemotaxis [PMID: 2211662]. They comprise a basal body, a hook and a filament, the latter accounting for 98% of the mass [PMID: 2498283]. Flagellin is the subunit protein that polymerises to form the flagellae [PMID: 3536885], the subunits being transported through the centre of the filament to the tip, where they then polymerise [PMID: 2211662]. Both the N- and C- termini of the subunit protein, which are alpha-helical in structure [PMID: 2211662], are required to mediate polymerisation. Although no export or assembly consensus sequences have been identified, Ala, Val, Leu, Ile, Gly, Ser, Thr, Asn, Gln and Asp tend to make up around 90% of the sequence, Cys and Trp being absent [PMID: 2498283].

This entry represents the N and C termini that come together to form the D0 and D1 structural domains [PMID: 12904785]. These domains are responsible for flagellin's ability to polymerise into a filament.

GO terms

Biological Process

GO:0071973 bacterial-type flagellum-dependent cell motility

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.