Dehydrogenase, E1 component (IPR001017)
Short name: DH_E1
Overlapping homologous superfamilies
- Thiamin diphosphate-binding fold (IPR029061)
This entry represents a domain found in a number of dehydrogenases, all of which use thiamine pyrophosphate as a cofactor and are members of a multienzyme complex:
- pyruvate dehydrogenase (EC:126.96.36.199), a component of the multienzyme pyruvate dehydrogenase complex
- 2-oxoglutarate dehydrogenase (EC:188.8.131.52), a component of the multienzyme 2-oxoglutarate dehydrogenase, which contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
- 2-oxoisovalerate dehydrogenase (EC:184.108.40.206), a component of the multienzyme branched-chain alpha-keto dehydrogenase complex.
Signatures from InterPro member databases are used to construct an entry.
- PF00676 (E1_dh)