Dehydrogenase, E1 component (IPR001017)

Short name: DH_E1

Overlapping homologous superfamilies

Domain relationships



This entry represents a domain found in a number of dehydrogenases, all of which use thiamine pyrophosphate as a cofactor and are members of a multienzyme complex:

  • pyruvate dehydrogenase (EC:, a component of the multienzyme pyruvate dehydrogenase complex
  • 2-oxoglutarate dehydrogenase (EC:, a component of the multienzyme 2-oxoglutarate dehydrogenase, which contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
  • 2-oxoisovalerate dehydrogenase (EC:, a component of the multienzyme branched-chain alpha-keto dehydrogenase complex.

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.