Ribonuclease III domain (IPR000999)

Short name: RNase_III_dom

Domain relationships



Prokaryotic ribonuclease III (EC: (gene rnc) [PMID: 3903434] is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs. RNase III is evolutionary related to a number of proteins including [PMID: 9241229]:

  • Saccharomyces cerevisiae (Baker's yeast) protein pac1, a ribonuclease that probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development
  • yeast ribonuclease III (gene RNT1), a dsRNA-specific nuclease that cleaves eukaryotic preribosomal RNA at various sites
  • Caenorhabditis elegans hypothetical protein F26E4.13
  • Paramecium bursaria Chlorella virus 1 (PBCV-1) 1 protein A464R
  • Synechocystis sp. (strain PCC 6803) hypothetical protein slr0346
  • yeast hypothetical protein SpAC8A4.08c, a protein with a N-terminal helicase domain and a C-terminal RNase III domain
  • C. elegans hypothetical protein K12H4.8, a protein with the same structure as SpAC8A4.08c

GO terms

Biological Process

GO:0006396 RNA processing

Molecular Function

GO:0003723 RNA binding
GO:0004525 ribonuclease III activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE profiles