Domain

Ribonuclease III domain (IPR000999)

Short name: RNase_III_dom

Domain relationships

None.

Description

Prokaryotic ribonuclease III (EC:3.1.26.3) (gene rnc) [PMID: 3903434] is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs. RNase III is evolutionary related to a number of proteins including [PMID: 9241229]:

  • Saccharomyces cerevisiae (Baker's yeast) protein pac1, a ribonuclease that probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development
  • yeast ribonuclease III (gene RNT1), a dsRNA-specific nuclease that cleaves eukaryotic preribosomal RNA at various sites
  • Caenorhabditis elegans hypothetical protein F26E4.13
  • Paramecium bursaria Chlorella virus 1 (PBCV-1) 1 protein A464R
  • Synechocystis sp. (strain PCC 6803) hypothetical protein slr0346
  • yeast hypothetical protein SpAC8A4.08c, a protein with a N-terminal helicase domain and a C-terminal RNase III domain
  • C. elegans hypothetical protein K12H4.8, a protein with the same structure as SpAC8A4.08c

GO terms

Biological Process

GO:0006396 RNA processing

Molecular Function

GO:0003723 RNA binding
GO:0004525 ribonuclease III activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE patterns
Pfam
GENE3D
PROSITE profiles
SUPERFAMILY
SMART