Adenoviral fibre protein, knob (IPR000978)

Short name: Adeno_fibre_knob

Overlapping homologous superfamilies

Domain relationships



Adenoviruses are responsible for diseases such as pneumonia, cystitis, conjunctivitis and diarrhoea, all of which can be fatal to patients who are immunocompromised [PMID: 7704534]. Viral infection commences with recognition of host cell receptors by means of specialised proteins on viral surfaces. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain. Fiber protein forms spikes that protrude from each vertex of the icosahedral capsid. Fiber proteins are shed during virus entry, when virus is still at the cell surface [PMID: 11152512, PMID: 22754652].

GO terms

Biological Process

GO:0019062 virion attachment to host cell

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0019028 viral capsid

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.