Octamer-binding transcription factor (IPR000972)

Short name: TF_octamer

Overlapping homologous superfamilies


Family relationships



The octamer-binding protein is a transcription factor that binds specifically to the octamer motif (ATTTGCAT)[PMID: 8474450] of immunoglobulin promoters and activates these genes. There are two Ig octamer-binding proteins, designated NF-A1 and NF-A2. NF-A1 is found in all cell types, while NF-A2 is found only in lymphoid cells. The sequences of these proteins contain a region that correponds closely to the DNA-binding homeobox domains and POU transcription factors.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.