Family

Stathmin family (IPR000956)

Short name: Stathmin_fam

Family relationships

Description

Stathmin [PMID: 1957351] (from the Greek 'stathmos' which means relay), is a ubiquitous intracellular protein, present in a variety of phosphorylated forms. It is involved in the regulation of the microtubule (MT) filament system by destabilising microtubules. It prevents assembly and promotes disassembly of microtubules [PMID: 14598370]. However, when phosphorylated, its destabilisation ability is significantly reduced [PMID: 11160824].

The stathmin family also includes:

  • Stathmin 2 (Protein SCG10); a neuron-specific, membrane-associated protein that accumulates in the growth cones of developing neurons. It is highly similar in its sequence to stathmin, but differs in that it contains an additional N-terminal hydrophobic segment of 32 residues which is probably responsible for its interaction with membranes.
  • Stathmin 3 (SCG10-like protein; SCLIP) [PMID: 9603203]; a protein specifically expressed in neurons.
  • Stathmin 4 (Stathmin-like protein B3); which contains an additional N- terminal hydrophobic domain [PMID: 9342231].

These proteins possess a stathmin-like domain (SLD) with various N-terminal extensions. SLD is a highly conserved domain of 149 amino acid residues. Structurally, it consists of an N-terminal domain of about 45 residues followed by a 78 residue alpha-helical domain consisting of a heptad repeat coiled coil structure and a C-terminal domain of 25 residues [PMID: 15014504, PMID: 11278715]. The SLD binds two tubulins arranged longitudinally, head-to-tail, in protofilament-like complexes.

GO terms

Biological Process

GO:0031110 regulation of microtubule polymerization or depolymerization

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam
PRINTS
PANTHER
PIRSF