Adenovirus fibre protein (IPR000931)

Short name: Adeno_fibre

Overlapping homologous superfamilies


Family relationships



Adenoviruses are responsible for diseases such as pneumonia, cystitis, conjunctivitis and diarrhoea, all of which can be fatal to patients who are immunocompromised [PMID: 7704534]. Viral infection commences with recognition of host cell receptors by means of specialised proteins on viral surfaces. The adenovirus fibre protein `knob domain' at the C terminus is one such receptor-binding protein subunit. The crystal structure of the knob domain reveals a trimeric organisation, each subdomain folded into 2 functionally distinct beta-sheets. The V sheet is highly conserved, and provides contact surfaces in the formation of the trimer, while the R sheet is more variable, and may play a role in viral-receptor interactions. The overall shape of the trimer resembles a 3-bladed propeller, with a central surface depression and 3 valleys formed by the symmetry-related R sheets. Sequence comparison of different types of adenovirus fibre protein suggests an overall similarity in the structure of the knob domain. The main conserved regions lie in the central surface depression around the 3-fold symmetry axis [PMID: 7704534]. The N terminus of the protein contains the 'shaft' region.

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0019058 viral life cycle
GO:0019062 virion attachment to host cell

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.