Family

Dopamine receptor family (IPR000929)

Short name: Dopamine_rcpt

Family relationships

Description

Dopamine receptors are members of the rhodopsin-like G-protein coupled receptor family and are prominent in the vertebrate central nervous system (CNS). Dysfunction of dopaminergic neurotransmission in the CNS has been implicated in a variety of neuropsychiatric disorders [PMID: 15148138], including social phobia [PMID: 10698826], Tourette's syndrome [PMID: 16613557], Parkinson's disease [PMID: 17017512], schizophrenia [PMID: 16613557], neuroleptic malignant syndrome [PMID: 12555236], attention-deficit hyperactivity disorder (ADHD) [PMID: 16961425] and drug and alcohol dependence [PMID: 16613557, PMID: 11920678]. As a result, dopamine receptors are common drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors [PMID: 9633679, PMID: 16433053, PMID: 14060771, PMID: 1060115].

There are at least five different known subtypes of dopamine receptors designated D1, D2, D3, D4 and D5 [PMID: 12836695]. They are distinguished by their G-protein coupling, ligand specificity, anatomical distribution and physiological effects. Dopamine receptors are divided into two further subfamilies. The D1-like family consists of D1 and D5 receptors, which couple to Gs and mediate excitatory neurotransmission. The D2-like family, meanwhile, consists of D2, D3 and D4 receptors, which couple to Gi/Go and mediate inhibitory neurotransmission. Although dopamine receptors are widely distributed in the brain, they are found in different locations that have different receptor type densities, presumably reflecting different functional roles [PMID: 9457173]. D1 and D2 receptor subtypes are found at 10-100 times the levels of the D3, D4, D5 subtypes [PMID: 16458973].

This entry represents the dopamine receptor family.

GO terms

Biological Process

GO:0007186 G-protein coupled receptor signaling pathway

Molecular Function

GO:0004952 dopamine neurotransmitter receptor activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS