Domain

Solute-binding protein family 5 domain (IPR000914)

Short name: SBP_5_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [PMID: 8003968, PMID: 18310026].

On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [PMID: 8336670] into eight families or clusters, which generally correlate with the nature of the solute bound. This entry represents a domain found in the solute-binding protein family 5.

Family 5 members include:

  • Periplasmic oligopeptide-binding proteins (oppA) of Gram-negative bacteria and homologous lipoproteins in Gram-positive bacteria (oppA, amiA or appA)
  • Periplasmic dipeptide-binding proteins of Escherichia coli (dppA) and Bacillus subtilis (dppE)
  • Periplasmic murein peptide-binding protein of E. coli (mppA)
  • Periplasmic peptide-binding proteins sapA of E. coli, Salmonella typhimurium and Haemophilus influenzae
  • Periplasmic nickel-binding protein (nikA) of E. coli
  • Haem-binding lipoprotein (hbpA or dppA) from H. influenzae
  • Lipoprotein xP55 from Streptomyces lividans
  • Hypothetical proteins from H. influenzae (HI0213) and Rhizobium sp. (strain NGR234) symbiotic plasmid (y4tO and y4wM)
  • HTH-type transcriptional regulator SgrR from E. coli. The solute-binding domain is localised in its C-terminal [PMID: 17209026].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam