Pathways & interactions
Solute-binding protein family 5 domain (IPR000914)
Short name: SBP_5_dom
Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [PMID: 8003968, PMID: 18310026].
On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [PMID: 8336670] into eight families or clusters, which generally correlate with the nature of the solute bound. This entry represents a domain found in the solute-binding protein family 5.
Family 5 members include:
- Periplasmic oligopeptide-binding proteins (oppA) of Gram-negative bacteria and homologous lipoproteins in Gram-positive bacteria (oppA, amiA or appA)
- Periplasmic dipeptide-binding proteins of Escherichia coli (dppA) and Bacillus subtilis (dppE)
- Periplasmic murein peptide-binding protein of E. coli (mppA)
- Periplasmic peptide-binding proteins sapA of E. coli, Salmonella typhimurium and Haemophilus influenzae
- Periplasmic nickel-binding protein (nikA) of E. coli
- Haem-binding lipoprotein (hbpA or dppA) from H. influenzae
- Lipoprotein xP55 from Streptomyces lividans
- Hypothetical proteins from H. influenzae (HI0213) and Rhizobium sp. (strain NGR234) symbiotic plasmid (y4tO and y4wM)
- HTH-type transcriptional regulator SgrR from E. coli. The solute-binding domain is localised in its C-terminal [PMID: 17209026].
- PF00496 (SBP_bac_5)