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Overview
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Pathways & interactions
Lipoxygenase (IPR000907)
Short name: LipOase
Overlapping homologous superfamilies
- Lipoxygenase, domain 3 (IPR027433)
- Lipoxigenase, C-terminal domain superfamily (IPR036226)
Family relationships
- Lipoxygenase (IPR000907)
- Lipoxygenase, mammalian (IPR001885)
- Lipoxygenase, plant (IPR001246)
Description
Lipoxygenases (EC:1.13.11.-) are a class of iron-containing dioxygenases which catalyses the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. They are common in plants where they may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. In mammals a number of lipoxygenases isozymes are involved in the metabolism of prostaglandins and leukotrienes [PMID: 3017195]. Sequence data is available for the following lipoxygenases:
- Plant lipoxygenases (EC:1.13.11.12). Plants express a variety of cytosolic isozymes as well as what seems to be a chloroplast isozyme [PMID: 7508918].
- Mammalian arachidonate 5-lipoxygenase (EC:1.13.11.34).
- Mammalian arachidonate 12-lipoxygenase (EC:1.13.11.31).
- Mammalian arachidonate 15-lipoxygenase B (also known as erythroid cell-specific 15-lipoxygenase; EC:1.13.11.33).
The iron atom in lipoxygenases is bound by four ligands, three of which are histidine residues [PMID: 8502991]. Six histidines are conserved in all lipoxygenase sequences, five of them are found clustered in a stretch of 40 amino acids. This region contains two of the three iron-ligands; the other histidines have been shown [PMID: 1567851] to be important for the activity of lipoxygenases.
GO terms
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0046872 metal ion binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Cellular Component
No terms assigned in this category.
Contributing signatures
- PTHR11771 (PTHR11771)