Family

Myotoxin (IPR000881)

Short name: Myotoxin

Family relationships

None.

Description

Myotoxins are small basic peptides (42 to 45 residues) that can cause severe muscle necrosis by a non-enzymatic mechanism. They act extremely rapidly and serve two primary biological functions: limiting the flight of prey by causing instantaneous paralysis of the hind limbs and promoting rapid death by paralysis of the diaphragm [PMID: 2253781, PMID: 1862521]. These myotoxins have a well-conserved structure containing six cysteines involved in three disulphide bridges.

One of the better studied myotoxins is crotamine, from South American rattlesnake Crotalus durissus terrificus. Crotamine is a multifunctional peptide with pharmacological interest; it can penetrate cells and has potential selective antitumoral activity together with its ability to inhibit the potassium current through voltage-gated potassium channels [PMID: 22498659]. Similar toxins have been isolated from the venom of other rattlesnake species [PMID: 16115660].

GO terms

Biological Process

GO:0044564 envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam
PROSITE patterns
PRINTS
ProDom