Family

Guanylin (IPR000879)

Short name: Guanylin

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry represents the guanylin family. Its members include guanylate cyclase activator 2A and 2B. They are endogenous activators of intestinal guanylate cyclases.

Guanylin, a 15-amino-acid peptide, is an endogenous ligand of the intestinal receptor guanylate cyclase-C, known as STaR [PMID: 7713512, PMID: 1409606]. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, it induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea [PMID: 1346555]. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins [PMID: 1409606].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030250 guanylate cyclase activator activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PRINTS
PIRSF
ProDom
PANTHER