Glycoside hydrolase, family 52 (IPR000852)

Short name: Glyco_hydro_52

Overlapping homologous superfamilies


Family relationships



O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 52 GH52 comprises enzymes with only one known activity; beta-xylosidase (EC:

Proteins harboring beta-xylosidase and xylanase activities [PMID: 8074507]have been identified in the Gram-positive, facultative thermophilic aerobe Bacillus stearothermophilus 21 [PMID: 8074507]. This microbe, which functions in xylan degradation, can utilise xylan as a sole source of carbon. The enzyme hydrolyses 1,4-beta-D-xylans, removing successive D-xylose residues from the non-reducing termini. It also hydrolyses xylobiose.

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0009044 xylan 1,4-beta-xylosidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.