Sugar phosphate transporter (IPR000849)

Short name: Sugar_P_transporter

Overlapping homologous superfamilies

Family relationships


Proteins in this group are involved in the transport system that mediates the uptake of a number of sugar phosphates as well as the regulatory components that are responsible for induction of this transport system by external glucose 6-phosphate. In Escherichia coli its role in transmembrane signalling may involve sugar-phosphate-binding sites and transmembrane orientations similar to those of the transport protein [PMID: 3301805]. The following proteins in this entry, involved in the uptake of phosphorylated metabolites, are evolutionary related [PMID: 3042749, PMID: 8438231]:

  • E. coli, Bacillus subtilis and Haemophilus influenzae glycerol-3- phosphate transporter (gene glpT).
  • Salmonella typhimurium phosphoglycerate transporter (gene pgtP).
  • E. coli and S. typhimurium hexose-6-phosphate transporter (gene uhpT).
  • E. coli and S. typhimurium protein uhpC. UhpC is necessary for the expression of uhpT and seems to act jointly with the uhpB sensor/kinase protein.
  • Human glucose 6-phosphate translocase [PMID: 9428641].

These proteins of about 50 kDa apparently contain 12 transmembrane regions.

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0022857 transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.