Family

ATP-binding cassette subfamily C member 8 (IPR000844)

Short name: ABCC8

Family relationships

Description

ATP-binding cassette subfamily C member 8 (ABCC8, also known as the sulphonylurea receptor SUR1) is a member of the ABC transporter family. ABCC8 is comprised of three transmembrane helical bundles, TMD0, TMD1 and TMD2. It also contains two cytosolic nucleotide binding domains (NBDs) located between TMD1 and TMD2 and in the cytoplasmic C-terminal domain, respectively [PMID: 25236767]. It is a regulator of the potassium ATP channel. Its NBD domains control channel activity through their interaction with cytosolic nucleotides [PMID: 18767144].

Together with ABCC9 (SUR2), ABCC8 regulates the Kir6.2 potassium channel [PMID: 10204114]. It also controls insulin secretion after feeding [PMID: 25143473]. ABCC8 and 9 are the targets of sulphonylurea oral hypoglycaemic agents that are used widely for the treatment of non-insulin dependent diabetes mellitus and ABCC8 genetic variants have been linked to risk of the disease [PMID: 24768178, PMID: 16416420].

GO terms

Biological Process

GO:0006813 potassium ion transport

Molecular Function

GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS
PANTHER