Conserved Site

Phosphoribosyl pyrophosphate synthetase, conserved site (IPR000842)

Short name: PRib_PP_synth_CS

Description

Phosphoribosyl pyrophosphate synthetase (EC:2.7.6.1) (PRib-PP synthetase) catalyses the formation of PRib-PP from ATP and ribose 5-phosphate. PRib-PP is then used in various biosynthetic pathways, for example in the formation of purines, pyrimidines, histidine and tryptophan. PRib-PP synthetase requires inorganic phosphate and magnesium ions for its stability and activity. In mammals, three isozymes of PRib-PP synthetase are found, while in yeast there are at least four isozymes. A very conserved region containing two conserved aspartic acid residues as well as a histidine has been suggested to be involved in binding divalent cations [PMID: 2542328]. These residues are all potential ligands for a cation such as magnesium.

GO terms

Biological Process

GO:0044249 cellular biosynthetic process
GO:0009156 ribonucleoside monophosphate biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns