Conserved Site

CC chemokine, conserved site (IPR000827)

Short name: Chemokine_CC_CS

Description

Many low-molecular weight factors secreted by cells including fibroblasts, macrophages and endothelial cells, in response to a variety of stimuli such as growth factors, interferons, viral transformation and bacterial products, are structurally related [PMID: 1910690, PMID: 2149646, PMID: 2687068]. Most members of this family of proteins seem to have mitogenic, chemotactic or inflammatory activities. These small cytokines are also called intercrines or chemokines. They are cationic proteins of 70 to 100 amino acid residues that share four conserved cysteine residues involved in two disulphide bonds. These proteins can be sorted into two groups based on the spacing of the two amino-terminal cysteines. In the first group, the two cysteines are separated by a single residue (C-x-C), while in the second group, they are adjacent (C-C). The 'C-C' group is currently known to include monocyte chemotactic proteins 1 (MCP-1), 2 (MCP-2), 3 and 4; macrophage inflammatory protein 1 alpha (MIP-1-alpha), beta (MIP-1-beta) and gamma (MIP-1-gamma); macrophage inflammatory protein 3 alpha and beta, 4 and 5; LD78 beta; SIS-epsilon (p500); thymus and activation-regulated chemokine (TARC); Eotaxin; I-309; human proteins HCC-1/NCC-2 and HCC-3; and mouse protein C10.

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0008009 chemokine activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns