Peptidase C15, pyroglutamyl peptidase I (IPR000816)

Short name: Peptidase_C15

Family relationships


This group of cysteine peptidases belong to MEROPS peptidase family C15 (pyroglutamyl peptidase I, clan CF). The type example being pyroglutamyl peptidase I of Bacillus amyloliquefaciens.

Pyroglutamyl/pyrrolidone carboxyl peptidase (Pcp or PYRase) is an exopeptidase that hydrolytically removes the pGlu from pGlu-peptides or pGlu-proteins [PMID: 7824521, PMID: 1353026]. PYRase has been found in prokaryotes and eukaryotes where at least two different classes have been characterised: the first containing bacterial and animal type I PYRases, and the second containing animal type II and serum PYRases. Type I and bacterial PYRases are soluble enzymes, while type II PYRases are membrane-bound. The primary application of PYRase has been its utilisation for protein or peptide sequencing, and bacterial diagnosis [PMID: 1353026]. The conserved residues Cys-144 and His-168 have been identified by inhibition and mutagenesis studies [PMID: 7824521, PMID: 7909543].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0016920 pyroglutamyl-peptidase activity

Cellular Component

GO:0005829 cytosol

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns