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Overview
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Pathways & interactions
Transcription factor TFIIB (IPR000812)
Short name: TFIIB
Overlapping homologous superfamilies
None.
Family relationships
- Transcription factor TFIIB (IPR000812)
- Transcription factor IIIB subunit Brf1 (IPR029529)
- Transcription initiation factor TFIIB, archaea (IPR023484)
Description
In eukaryotes, transcription initiation by polymerase II is modulated by both general and specific transcription factors. The general factors (which include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIG and TFIIH) operate through common promoter elements, such as the TATA box. Transcription factor IIB (TFIIB) is of central importance in transcription of class II genes. It associates with TFIID-TFIIA bound to DNA (the DA complex) to form a ternary TFIID-IIA-IBB (DAB) complex, which is recognised by RNA polymerase II [PMID: 1876184, PMID: 1949150]. TFIIB comprises ~315-340 residues and contains an imperfect C-terminal repeat of a 75-residue domain that may contribute to the symmetry of the folded protein.
Proteins in this entry also include transcription factor IIIB subunit Brf1, which shares protein sequence similarity with TFIIB. In budding yeast, Brf1 interacts with several initiation-specific subunits of the pol III machinery, TBP, beta", TFC4p and the pol III subunits C34 and C17 [PMID: 11433012].
GO terms
Biological Process
GO:0070897 DNA-templated transcriptional preinitiation complex assembly
GO:0006355 regulation of transcription, DNA-templated
Molecular Function
No terms assigned in this category.
Cellular Component
No terms assigned in this category.