Cyclin-dependent kinase, regulatory subunit (IPR000789)

Short name: Cyclin-dep_kinase_reg-sub

Overlapping homologous superfamilies

Family relationships



In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle progression, and are required for the G1 and G2 stages of cell division [PMID: 3322810]. The proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS), which is essential for their function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms. The regulatory subunits exist as hexamers, formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual 12-stranded beta-barrel structure [PMID: 8211159]. Through the barrel centre runs a 12A diameter tunnel, lined by 6 exposed helix pairs [PMID: 8491379]. Six kinase units can be modelled to bind the hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase multimerisation [PMID: 8491379, PMID: 8211159].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns