Family

Cyclin-dependent kinase, regulatory subunit (IPR000789)

Short name: Cyclin-dep_kinase_reg-sub

Overlapping homologous superfamilies

Family relationships

None.

Description

In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle progression, and are required for the G1 and G2 stages of cell division [PMID: 3322810]. The proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS), which is essential for their function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms. The regulatory subunits exist as hexamers, formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual 12-stranded beta-barrel structure [PMID: 8211159]. Through the barrel centre runs a 12A diameter tunnel, lined by 6 exposed helix pairs [PMID: 8491379]. Six kinase units can be modelled to bind the hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase multimerisation [PMID: 8491379, PMID: 8211159].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS
PROSITE patterns
PROSITE patterns
SMART
Pfam