Enhancer of rudimentary (IPR000781)

Short name: ERH

Overlapping homologous superfamilies

Family relationships



The Drosophila protein 'enhancer of rudimentary' (gene (e(r)) is a small protein of 104 residues whose function is not yet clear. From an evolutionary point of view, it is highly conserved [PMID: 9074495] and has been found to exist in probably all multicellular eukaryotic organisms. ERH has been implicated in the regulation of pyrimidine biosynthesis, DNA replication, transcription, mRNA splicing, cellular proliferation, tumorigenesis, and the Notch signaling pathway [PMID: 27830090]. Fission yeast homologue of ERH is implicated in meiotic mRNA elimination during vegetative growth. It forms a stoichiometric complex with Mmi1 to promote meiotic mRNA decay and facultative heterochromatin assembly [PMID: 26942678, PMID: 29424342].

ERH has been shown to interact with SAFB1/SAFB2 (scaffold attachment factor-B 1/2)at the nuclear matrix to regulate SR protein phosphorylation [PMID: 28627136].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns