Family

Granulocyte-macrophage colony-stimulating factor (IPR000773)

Short name: GM_colony-stim-fac

Family relationships

None.

Description

Granulocyte-macrophage colony-stimulating factor (GMCSF) is a cytokine that acts in hematopoiesis to stimulate growth and differentiation of hematopoietic precursor cells from various lineages including granulocytes, macrophages, eosinophils and erythrocytes [PMID: 2458827, PMID: 1569568]. GMCSF is a glycoprotein of ~120 residues that contains 4 conserved cysteines that participate in disulphide bond formation. The crystal structure of recombinant human GMCSF has been determined [PMID: 1569568]. There are two molecules in the asymmetric unit, which are related by an approximate non-crystallographic 2-fold axis. The overall structure, which is highly compact and globular with a predominantly hydrophobic core, is characterised by a 4-alpha-helix bundle. The helices are arranged in a left-handed anti-parallel fashion, with two overhand connections. Within the connections is a two-stranded anti-parallel beta-sheet. The tertiary structure has a topology similar to that of Sus scrofa (pig) growth factor and interferon-beta. Most of the proposed critical regions for receptor binding are located on a continuous surface at one end of the molecule that includes the C terminus [PMID: 1569568].

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding
GO:0008083 growth factor activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
PROSITE patterns
Pfam
SMART
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PRINTS