Family

NAD:arginine ADP-ribosyltransferase, ART (IPR000768)

Short name: ART

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Mono-ADP-ribosylation is a post-translational modification of proteins in which the ADP-ribose moiety of NAD is transferred to proteins. This process is responsible for the toxicity of some bacterial toxins (e.g., cholera and pertussis toxins). Mono (ADP-ribosyl) transferases exist in vertebrates EC:2.4.2.31 that transfer ADP-ribose to arginine [PMID: 8703012]. NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine At least five forms of the enzyme have been characterised to date, some of which are attached to the membrane via glycosylphosphatidylinositol (GPI) anchors, while others appear to be secreted. The enzymes contain ~250-300 residues, which encode putative signal sequences and carbohydrate attachment sites. In addition, the N- and C-termini are predominantly hydrophobic, a characteristic of GPI-anchored proteins [PMID: 7947688].

GO terms

Biological Process

GO:0006471 protein ADP-ribosylation

Molecular Function

GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE patterns
PRINTS