WHEP-TRS domain (IPR000738)

Short name: WHEP-TRS_dom

Overlapping homologous superfamilies

Domain relationships



A conserved domain of 46 amino acids, called WHEP-TRS has been shown [PMID: 1756734] to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in mammalian multifunctional aminoacyl-tRNA synthetase in a region that separates the N-terminal glutamyl-tRNA synthetase domain from the C-terminal prolyl-tRNA synthetase domain, and six copies in the intercatalytic region of the Drosophila enzyme. The domain is found at the N-terminal extremity of the mammalian tryptophanyl- tRNA synthetase and histidyl-tRNA synthetase, and the mammalian, insect, nematode and plant glycyl- tRNA synthetases [PMID: 8463296]. The structure of a human WHEP-TRS domain has been solved and consists of two helices arranged in a helix-turn-helix [PMID: 11123902]. The WHEP-TRS domain may play a role in the association of tRNA-synthetases into multienzyme complexes [PMID: 9556618].

GO terms

Biological Process

GO:0006418 tRNA aminoacylation for protein translation

Molecular Function

GO:0005524 ATP binding
GO:0004812 aminoacyl-tRNA ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
PROSITE patterns