Rhodopsin (IPR000732)

Short name: Rhodopsin

Overlapping homologous superfamilies

Family relationships


The photoreceptor rhodopsin is a complex of the vision protein opsin and the chromophore 11-cis-retinal (derived from vitamin A). Light-sensitive pigments occur in both the rod cells (black and white vision) and cone cells (colour vision) in the retina at the back of the eye. Although related, the differences in sequence between the opsins accounts for their differences in absorption: rhodopsin in rod cells, and blue, red, and green opsins in cone cells. Upon exposure to light, the 11-cis-retinal attached to rod or cone opsin isomerises to all-trans-retinal, which leads to the activation of the G protein transducin, and ultimately to the hyperpolarisation of the cell and the propagation of a nerve impulse that is perceived as light.

This entry represents rhodopsins. It also matches some sequences designated as opsins, but whose sequence characteristics place them in the rhodopsin class, rather than that of their respective pigments.

GO terms

Biological Process

GO:0007186 G-protein coupled receptor signaling pathway
GO:0007602 phototransduction

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.